… This has significant implications for the application of mesenchymal stem cell therapy in
children with CHD, as our laboratory has demonstrated an age-dependent decline in the …

Stem cells have been touted as the holy grail of medical therapy, with promises to regenerate
cardiac tissue, but it appears the jury is still out on this novel therapy. Using advanced …

… therapeutic approaches to effectively treat or even cure CVD … way towards the use of gene
therapy as a novel treatment … In particular, lipid micro-bubbles carrying VEGF and stem cell …

… , led to the rapid translation of SC therapies within the same year [4… and so far, no cell therapy
has been unambiguously shown … stem and progenitor cells towards a cardiomyogenic fate …

… translation of stem cell therapy for patients with CHD. The TICAP study is the first example
of this interplay between breakthroughs in CSC biology and attention to the unmet clinical …

… investigation as a cell-based therapeutic strategy for cardiac … the data supporting the
translation of MSC therapy to clinical … killer cells are important innate cells in the defense against …

… bone marrow stem cells, the rationale for stem cell delivery … limited the clinical translation of
hESCs for cardiac therapy. … such as potential differentiation towards alternative cell fates and …

… and other forms of CHD. This article reviews the many stem cell types applied to CHD, their
… Stem Cell Therapy for CHD: Towards Translation. Cardiol Young 2015;25:58-66. HLHS, …

… efforts to translate iPSC-derived blood cells toward clinical use, with the main focus on
hematopoietic stem cells (… The clinical translation of induced pluripotent stem cell (iPSC)-derived …

… (BMDSCs) have been one of the most heavily tested cell types in the treatment of
cardiovascular disease to date. Previous studies have shown that autologous bone marrow …